Physicochemical Determinants of Antimicrobial Activity Supplemental Materials
نویسندگان
چکیده
A total of 35 active cathelicidin sequences were extracted from UniProt [10] (http://www.uniprot.org). Only reviewed sequences were considered and Protegrin-1 and related sequences [Swiss-Prot:UniRef90 P32194] were excluded. Evidence suggests these form a β-sheet upon membrane contact [9]. Uniprot GFF files were used to determine the start of the active peptide and precursor regions were discarded.
منابع مشابه
Physicochemical Determinants of Antimicrobial Activity
Antimicrobial peptides (AMPs) are lately receiving significant attention as targets for antibacterial drug research. While many machine learning techniques are shown effective for AMP recognition, their utility for the rational design of novel AMP-based drugs in the wet laboratory is questionable. In this paper we seek to elucidate determinants of antimicrobial activity in a well-studied class ...
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تاریخ انتشار 2013